UP109 | VCP activator | Probechem Biochemicals

Chemical Structure : UP109

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UP109 (UP-109, UP 109)

货号: PC-22572Not For Human Use, Lab Use Only.

UP109 is a small molecule activator of VCP ATPase activity with EC50 of 24.7 uM, Emax of 197%, activates VCP primarily by increasing D2 ATPase activity.

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生物&药学活性

UP109 is a small molecule activator of VCP ATPase activity with EC50 of 24.7 uM, Emax of 197%, activates VCP primarily by increasing D2 ATPase activity.
UP109 has at least some specificity for VCP over other AAA+ ATPases.
UP109 likely binds in the D2 ATPase domain of VCP.
UP109 (5 uM) effectively enhances clearance of TDP-4FL aggregates in cells expressing GFP-TDP-4FL.
UP109 is also effective in assisting clearance of TDP-4FL aggregates in iPSC-derived neurons.

物理化学性质&存储条件

分子量	454.47
分子式	C17H18N4O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(2-methoxyethyl)ureido)-2-oxoethyl 2-((4-methylthiazol-2-yl)thio)-5-nitrobenzoate

参考文献

1. Phan JM, et al. J Clin Invest. 2024 May 23:e169039.

UP109 (UP-109, UP 109)

生物&药学活性

物理化学性质&存储条件

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UP109 (UP-109, UP 109)

生物&药学活性

物理化学性质&存储条件

参考文献

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