UNI418 | PIKfyve/PIP5K1C inhibitor | Probechem Biochemicals

Chemical Structure : UNI418

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UNI418 (UNI-418)

货号: PC-22798Not For Human Use, Lab Use Only.

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生物&药学活性

UNI418 (UNI-418) is a potent, specific dual PIKfyve and PIP5K1C inhibitor with IC50 of 60.7 nM/60.1 nM for PIP5K1B/PIP5K1C, Kd of 0.78 nM for PIKfyve (100% inhibition at 1 uM), inhibits UNI418 inhibits SARS-CoV-2 infection of Vero cells with IC50 of 1.4 uM.
UNI418 inhibits autophagy, blocks autophagic flux by measuring the turnover rate of LC3-II in RPE1 cells, inhibits autophagosome-lysosome fusion and endolysosomal acidification.
UNI418 inhibits cathepsin maturation by preventing PIKfyve-dependent lysosomal trafficking, which is relevant to SARS-CoV-2 spike protein cleavage.
UNI418 efficiently inhibited SARS-CoV-2 replication in cells and reduced the production of progeny virus in culture supernatants.
UNI418 inhibits SARS-CoV-2 spike-mediated pseudovirus entry through PIP5K1C and PIKfyve.

物理化学性质&存储条件

分子量	364.41
分子式	C22H16N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)-4-quinazolinamine

参考文献

1. Yuri Seo, et al. Exp Mol Med. 2024 Aug 1. doi: 10.1038/s12276-024-01283-2.

UNI418 (UNI-418)

生物&药学活性

物理化学性质&存储条件

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UNI418 (UNI-418)

生物&药学活性

物理化学性质&存储条件

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