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首页-小分子抑制剂&激动剂-Others-Other Targets-UNC9750
UNC9750

Chemical Structure : UNC9750

CAS No.: 2967648-29-7

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UNC9750 (UNC 9750, UNC-9750)

货号: PC-22397Not For Human Use, Lab Use Only.

UNC9750 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 31.6 nM, inhibits human glioblastoma cell growth and selectively decreases cellular InsP5 abundance.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UNC9750 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 31.6 nM, inhibits human glioblastoma cell growth and selectively decreases cellular InsP5 abundance.
UNC9750 (10 µM, 48 hours) selectively and effectively inhibits InsP5 levels, without affecting InsP6 in human U251-MG glioblastoma cell.
UNC9750 displays excellent in vivo pharmacokinetics.

物理化学性质&存储条件

分子量 400.49
分子式 C23H24N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-(1-cyclobutylpiperidin-4-yl)phenyl)-5-(1H-tetrazol-5-yl)benzo[c]isoxazole

参考文献

1. Yubai Zhou, et al. bioRxiv [Preprint]. 2024 May 14:2024.05.09.593371.

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