UNC9512 | 53BP1 inhibitor | Probechem Biochemicals

Chemical Structure : UNC9512

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UNC9512 (UNC 9512)

货号: PC-21489Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

UNC9512 is a selective methyl-lysine reader p53 binding protein 1 (53BP1) antagonist, binds the 53BP1 tandem Tudor domain (TTD) with TR-FRET IC50 of 0.46 uM, and SPR/ITC Kd vfalues of 0.17/0.41 uM respectively.
UNC9512 shows no measurable binding affinity (>100 μM) for all other reader domains, including Tudor domains (SETDB1, UHRF1, and PHF19), plant homeodomains (PHF19 and KDM7B), and chromodomains (CBX2, CDYL2, and MPP8).
UNC9512 antagonizes the 53BP1 TTD:H4 interaction IC50 values of 6.9 μM in cell-based assays.
UNC9512 is a potent and selective chemical probe for 53BP1 that could be useful in gene-editing applications.
P53-binding protein 1 (53BP1) is a Kme reader protein that has been observed to play a crucial role in mediating DDR mechanisms. 53BP1 was originally recognized for its binding to methylated p53, 53BP1 is also recruited to dimethylated lysine 20 on histone H4 (H4K20me2) via the tandem Tudor domain (TTD) of the protein.

物理化学性质&存储条件

分子量	538.65
分子式	C31H34N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-(4-Methylpiperazin-1-yl)picolinoyl)-N-(3-(3-oxoisoindolin-5-yl)phenyl)piperidine-3-carboxamide

参考文献

1. Devan J Shell, et al. J Med Chem. 2023 Oct 26;66(20):14133-14149.

UNC9512 (UNC 9512)

生物&药学活性

物理化学性质&存储条件

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UNC9512 (UNC 9512)

生物&药学活性

物理化学性质&存储条件

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