UNC4976 | CBX7 modulator | Probechem Biochemicals

Chemical Structure : UNC4976

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UNC4976 (UNC-4976)

货号: PC-38261Not For Human Use, Lab Use Only.

UNC4976 (UNC-4976) is a potent cellular active positive allosteric modulator of CBX7, binds to CBX7 competitively with H3K27me3 peptides (IC50=20 nM), while increasing affinity for oligonucleotides.

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生物&药学活性

UNC4976 (UNC-4976) is a potent cellular active positive allosteric modulator of CBX7, binds to CBX7 competitively with H3K27me3 peptides (IC50=20 nM), while increasing affinity for oligonucleotides.
UNC4976 displays >40-fold selectivity over CBX8 (IC50=890 nM).
The PAM activity of UNC4976 resulted in enhanced efficacy across three orthogonal cellular assays by simultaneously antagonizing H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.
UNC4976 reequilibrates PRC1 away from H3K27me3 target regions.

物理化学性质&存储条件

分子量	847.111
分子式	C47H70N6O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl N6-(bicyclo[2.2.1]heptan-2-yl)-N2-(4-(tert-butyl)benzoyl)-L-phenylalanyl-L-alanyl-L-leucyl-N6-methyl-L-lysyl-L-serinate

参考文献

1. Kelsey N Lamb, et al. Cell Chem Biol. 2019 Oct 17;26(10):1365-1379.e22.

UNC4976 (UNC-4976)

生物&药学活性

物理化学性质&存储条件

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UNC4976 (UNC-4976)

生物&药学活性

物理化学性质&存储条件

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