UNC2383 | Endosomolytic compound | Probechem Biochemicals

Chemical Structure : UNC2383

CAS No.: 2123481-48-9

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UNC2383 (UNC-2383)

货号: PC-72947Not For Human Use, Lab Use Only.

UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).
UNC2383 is capable of boosting ON activity by inducing ON escape from late endosomes at concentrations of 5-30 uM to boost oligonucleotides (ONs) activity.

物理化学性质&存储条件

分子量	408.886
分子式	C22H21ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)benzofuran-2-carboxamide

参考文献

1. Jeremy P Bost, et al. Commun Biol. 2022 Mar 1;5(1):185.

2. B Yang, et al. Nucleic Acids Res. 2015 Feb 27;43(4):1987-96.

3. Ling Wang, et al. ACS Chem Biol. 2017 Aug 18;12(8):1999-2007.

UNC2383 (UNC-2383)

生物&药学活性

物理化学性质&存储条件

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UNC2383 (UNC-2383)

生物&药学活性

物理化学性质&存储条件

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