UNC1999 | EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : UNC1999

CAS No.: 1431612-23-5

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UNC1999 (UNC 1999)

货号: PC-21940Not For Human Use, Lab Use Only.

UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3680	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively.
UNC1999 is highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets.
UNC1999 potently reduces H3K27me3 levels in cells and selectively killed diffused large B cell lymphoma cell lines harboring the EZH2(Y641N) mutant.
UNC1999 prolongs survival of a well-defined murine leukemia model bearing MLL-AF9.

物理化学性质&存储条件

分子量	569.75
分子式	C33H43N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

参考文献

1. Grinshtein N, et al. Oncotarget. 2016 Sep 13;7(37):59360-59376.

2. Xu B, et al. Blood. 2015 Jan 8;125(2):346-57.

3. Konze KD, et al. ACS Chem Biol. 2013;8(6):1324-34.

UNC1999 (UNC 1999)

生物&药学活性

物理化学性质&存储条件

参考文献

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UNC1999 (UNC 1999)

生物&药学活性

物理化学性质&存储条件

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