UNC10245380 | CIB1 inhibitor | Probechem Biochemicals

Chemical Structure : UNC10245380

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UNC10245380 (UNC5380)

货号: PC-22593Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UNC10245380 (UNC5380) is a small molecule ligand/inhibitor of Calcium and Integrin Binding protein 1 (CIB1) with IC50 of 8.0 uM in TR-FRET displacement assay, selectively kills CIB1 depletion-sensitive TNBC cells.
UNC10245380 shows significant cell killing activity in both CIB1-depletion-sensitive (MDA-MB-461, and MDA-MB-468) cell lines.
UNC10245380 shows no activity in the CIB1-depletion-insensitive (MDA-MB-231) cell line.
UNC10245380 also shows >90% dose-dependent cell death of MDA-468 TNBC cells over 48 h, indicating a more robust and rapid cell death than CIB1 shRNA depletion by 72 h.
UNC10245380 inhibits AKT and ERK phosphorylation in CIB1 depletion-sensitive, but not insensitive cell lines.
) upregulates γH2AX and inhibits AKT and ERK phosphorylation in CIB1 depletion-sensitive, but not insensitive cell lines.
UNC10245380 closely parallels the CIB1 depletion cell death and signaling phenotypes in TNBC cells.

物理化学性质&存储条件

分子量	578.13
分子式	C30H32ClN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chlorobenzyl)-4-((2-((2-((5-methyl-1H-pyrazol-3-yl)amino)-2-oxoethyl)thio)-4-oxo-3,4-dihydroquinolin-3-yl)methyl)cyclohexane-1-carboxamide

参考文献

1. An Y, et al. Nat Commun. 2024 Jul 2;15(1):5564.

UNC10245380 (UNC5380)

生物&药学活性

物理化学性质&存储条件

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UNC10245380 (UNC5380)

生物&药学活性

物理化学性质&存储条件

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