UNC0642 | G9a/GLP inhibitor | Probechem Biochemicals

Chemical Structure : UNC0642

CAS No.: 1481677-78-4

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UNC0642 (UNC-0642, UNC 0642)

货号: PC-49728Not For Human Use, Lab Use Only.

UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM.
UNC0642 displays >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases.
UNC0642 reduces H3K9 dimethylation levels with IC50 of <150 nM in U2OS, PC3, and PANC-1 cells, exhibits excellent potency (IC50 = 40 nM) in PANC-1 cells.
UNC0642 reduces clonogenicity in PANC-1 cells in a concentration-dependent manner while it had no effect on clonogenicity in MDA-MB-231 cells.

物理化学性质&存储条件

分子量	546.71
分子式	C29H44F2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

参考文献

1. Feng Li, et al. J Med Chem. 2013 Nov 14;56(21):8931-42.

2. Sebastian Scheer, et al. Nat Commun. 2019 Jan 3;10(1):19.

UNC0642 (UNC-0642, UNC 0642)

生物&药学活性

物理化学性质&存储条件

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UNC0642 (UNC-0642, UNC 0642)

生物&药学活性

物理化学性质&存储条件

参考文献

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