UNC0379 trifluoroacetate |CAS:1620401-83-3 Probechem Biochemicals

Chemical Structure : UNC0379 trifluoroacetate

CAS No.: 1620401-83-3

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UNC0379 trifluoroacetate (UNC-0379 trifluoroacetate)

货号: PC-42984Not For Human Use, Lab Use Only.

UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.

规格	价格	库存
5 mg	￥980	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg	￥6280	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM).
UNC0379 causes neuroblastoma (NB) cell growth inhibition which is p53 dependent.
UNC0379 reduces levels of p53K382me1 modification in xenografts.

物理化学性质&存储条件

分子量	527.5797
分子式	C25H36F3N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-, 2,2,2-trifluoroacetate (1:x)

参考文献

1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.

2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.

3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.

UNC0379 trifluoroacetate (UNC-0379 trifluoroacetate)

生物&药学活性

物理化学性质&存储条件

参考文献

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UNC0379 trifluoroacetate (UNC-0379 trifluoroacetate)

生物&药学活性

物理化学性质&存储条件

参考文献

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