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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-UNC0379
UNC0379

Chemical Structure : UNC0379

CAS No.: 1620401-82-2

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UNC0379 (UNC 0379, UNC-0379)

货号: PC-42983Not For Human Use, Lab Use Only.

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
UNC0379 displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM).
UNC0379 causes neuroblastoma (NB) cell growth inhibition which is p53 dependent, reduces levels of p53K382me1 modification in xenografts.

物理化学性质&存储条件

分子量 413.5563
分子式 C23H35N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

参考文献

1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.

2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.

3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.

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