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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-UNC0321
UNC0321

Chemical Structure : UNC0321

CAS No.: 1238673-32-9

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UNC0321 (UNC 0321;UNC-0321)

货号: PC-42741Not For Human Use, Lab Use Only.

UNC0321 (UNC-0321) is a highly potent, selective histone methyltransferase G9a inhibitor with Ki of 63 pM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UNC0321 (UNC-0321) is a highly potent, selective histone methyltransferase G9a inhibitor with Ki of 63 pM.
UNC0321 inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays.
UNC0321 dispalys >1000-fold selectivity for G9a over SET7/9, SET8, PRMT3 and JMJD2E (IC50>4 uM); but lacks sufficient cellular potency.

物理化学性质&存储条件

分子量 515.6913
分子式 C27H45N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-

参考文献

1. Liu F, et al. J Med Chem. 2010 Aug 12;53(15):5844-57.

2. Liu F, et al. J Med Chem. 2011 Sep 8;54(17):6139-50.

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