UNC-SOB-5-16

Chemical Structure : UNC-SOB-5-16

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货号: PC-21868Not For Human Use, Lab Use Only.

UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.

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生物&药学活性

UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.
UNC-SOB-5-16 displays high selectivity in the DiscoveRx KINOMEscan panel of 451 kinase assays, only 10 kinases give a percent of control (PoC) <90% at 1 uM.
UNC-SOB-5-16 shows affinity to STK3 in live cells in the STK3-NanoBRET assay with IC50 of 2.7 uM.
UNC-SOB-5-16 inhibits HVMP2 spheroid growth by more than 50% at 10 μM doses.

物理化学性质&存储条件

分子量	263.30
分子式	C15H13N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

参考文献

1. Henderson J.L., et al. J. Med. Chem. 2015;58:419–432.

2. Amelia U Schirmer, et al. Mol Ther. 2022 Jan 5;30(1):485-500.

UNC-SOB-5-16

生物&药学活性

物理化学性质&存储条件

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UNC-SOB-5-16

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物理化学性质&存储条件

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