UNC-BE4-017

Chemical Structure : UNC-BE4-017

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货号: PC-21869Not For Human Use, Lab Use Only.

UNC-BE4-017 is a selective STK3 small-molecule inhibitor, also potently inhibits JAK1, JAK2, and JAK3, but not other kinases in a panel of 48 kinases.

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生物&药学活性

UNC-BE4-017 is a selective STK3 small-molecule inhibitor, also potently inhibits JAK1, JAK2, and JAK3, but not other kinases in a panel of 48 kinases.
UNC-BE4-017 shows affinity to STK3 in live cells in the STK3-NanoBRET assay with IC50 of 7.6 uM.
UNC-BE4-017 inhibits prostate cancer (PC) cell proliferation.

物理化学性质&存储条件

分子量	286.38
分子式	C16H22N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-cyclopropyl-N-(3,3-dimethylbutan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

参考文献

1. Amelia U Schirmer, et al. Mol Ther. 2022 Jan 5;30(1):485-500.

UNC-BE4-017

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物理化学性质&存储条件

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UNC-BE4-017

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物理化学性质&存储条件

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