UMM-766 | Orthopoxvirus inhibitor | Probechem Biochemicals

Chemical Structure : UMM-766

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UMM-766 (UMM766, 7-fluoro-7-deaza-2'-C-methyladenosine)

货号: PC-21831Not For Human Use, Lab Use Only.

UMM-766 is an orally available nucleoside analog with potent, broad-spectrum antiviral activity against multiple members of orthopoxviruses (EC50<1 uM against VACV).

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200 mg		Get quote

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生物&药学活性

UMM-766 is an orally available nucleoside analog with potent, broad-spectrum antiviral activity against multiple members of orthopoxviruses (EC50<1 uM against VACV).
UMM-766 has relatively less effective against CPXV having EC50 of 2.17 and 8.09 µM in RAW and MRC5 cells, respectively.
UMM-766 (oral 10 mg/kg) protected mice against disease in the semi-lethal VACV murine model.

物理化学性质&存储条件

分子量	298.27
分子式	C12H15FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4R,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol

参考文献

1. Eldrup AB, et al. 2004. Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. J Med Chem 47:5284–5297.

2. Mudhasani RR, et al. Microbiol Spectr. 2024 Feb 23:e0358623.

UMM-766 (UMM766, 7-fluoro-7-deaza-2'-C-methyladenosine)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

UMM-766 (UMM766, 7-fluoro-7-deaza-2'-C-methyladenosine)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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