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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Kinesin-UMK57
UMK57

Chemical Structure : UMK57

CAS No.: 342595-74-8

UMK57 (UMK 57)

货号: PC-73363Not For Human Use, Lab Use Only.

UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells.
UMK57 targets MCAK in vivo but does not alter its levels or localization in cells.
UMK57 reduces lagging chromosome rates in human cancer cell lines by destabilizing kinetochore-microtubule (k-MT) attachments in metaphase.
UMK57 causes chromosome mis-segregation rebounds in UMK57-treated cancer cells.
UMK57 rescues age‐associated CIN and delays senescence.
UMK57 improves chromosome segregation fidelity in elderly cells, does not impact the mitotic fitness of younger cells.

物理化学性质&存储条件

分子量 295.404
分子式 C17H17N3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(4-methylphenyl)-4-(1-pyrrolidinyl)thieno[2,3-d]pyrimidine

参考文献

1. Bernardo Orr, et al. Cell Rep. 2016 Nov 8;17(7):1755-1763.

2. Monika Barroso-Vilares, et al. EMBO Rep. 2020 May 6;21(5):e49248.

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