UMB-136 |CAS:2109805-83-4 Probechem Biochemicals

Chemical Structure : UMB-136

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UMB-136 (UMB136;UMB 136)

货号: PC-60388Not For Human Use, Lab Use Only.

UMB-136 (UMB136) is a novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation.

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1 g		Get quote

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生物&药学活性

UMB-136 (UMB136) is a novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation.
UMB-136 dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association.
UMB-136 enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.

物理化学性质&存储条件

分子量	417.513
分子式	C24H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclohexyl-2-(4-(3,5-dimethylisoxazol-4-yl)-2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine

参考文献

1. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035.

UMB-136 (UMB136;UMB 136)

生物&药学活性

物理化学性质&存储条件

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UMB-136 (UMB136;UMB 136)

生物&药学活性

物理化学性质&存储条件

参考文献

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