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首页-小分子抑制剂&激动剂-Apoptosis-Apoptosis Inducer-UM4118
UM4118

Chemical Structure : UM4118

CAS No.: 75358-95-1

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UM4118 (UM-4118)

货号: PC-22058Not For Human Use, Lab Use Only.

UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis.
UM4118 is able to complex metals, in particular copper and zinc.
UM4118 acts as a copper ionophore which cytotoxicity relies on mitochondrial respiration
UM4118 induces cell death by cuproptosis
ABCB7 overexpression partially rescued UM4118-induced cell death in SF3B1-mutated cells.

物理化学性质&存储条件

分子量 248.29
分子式 C16H12N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(naphthalen-1-yl)picolinamide

参考文献

1. Céline Moison, et al. Sci Adv. 2024 Mar 22;10(12):eadl4018.

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