UM171 | LSD1 degrader | Probechem Biochemicals

Chemical Structure : UM171

CAS No.: 1448724-09-1

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UM171 (UM-171)

货号: PC-62316Not For Human Use, Lab Use Only.

UM171 (UM-171) is a potent agonist of human hematopoietic stem cell (HSC) self-renewal, shows 10 to 20 times more potent than UM729 with effective concentrations of 17 to 19 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UM171 (UM-171) is a potent agonist of human hematopoietic stem cell (HSC) self-renewal, shows 10 to 20 times more potent than UM729 with effective concentrations of 17 to 19 nM.
UM171 modulates the CoREST complex and causes LSD1 degradation, potentiates the activity of a CULLIN3-E3 ubiquitin ligase (CRL3) complex.
UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins.
UM171 (UM-171) enables a robust ex vivo expansion of human CB cells with functionally validated long-term in vivo repopulating capability.

物理化学性质&存储条件

分子量	487.94
分子式	C25H27N9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine

参考文献

1. Fares I, et al. Science. 2014 Sep 19;345(6203):1509-12.

2. Li X, et al. Stem Cell Res. 2017 May;21:32-39.

3. Zonari E, et al. Stem Cell Reports. 2017 Apr 11;8(4):977-990.

UM171 (UM-171)

生物&药学活性

物理化学性质&存储条件

参考文献

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UM171 (UM-171)

生物&药学活性

物理化学性质&存储条件

参考文献

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