UM-164 |CAS:903564-48-7 Probechem Biochemicals

Chemical Structure : UM-164

CAS No.: 903564-48-7

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UM-164 (UM164)

货号: PC-63476Not For Human Use, Lab Use Only.

UM-164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

UM-164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β.
UM-164 inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells.
UM-164 completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM.
UM-164 demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity.

物理化学性质&存储条件

分子量	640.686
分子式	C30H31F3N8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-5-thiazolecarboxamide

参考文献

1. Gilani RA, et al. Clin Cancer Res. 2016 Oct 15;22(20):5087-5096.

UM-164 (UM164)

生物&药学活性

物理化学性质&存储条件

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UM-164 (UM164)

生物&药学活性

物理化学性质&存储条件

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