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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-UK-500001
UK-500001

Chemical Structure : UK-500001

CAS No.: 582332-31-8

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UK-500001 (UK 500001, UK 500,001)

货号: PC-60726Not For Human Use, Lab Use Only.

UK-500001 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UK-500001 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.

    物理化学性质&存储条件

    分子量 499.49
    分子式 C26H24F3N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3,4-difluorophenoxy)-5-fluoro-N-((1s,4s)-4-(2-hydroxy-5-methylbenzamido)cyclohexyl)nicotinamide

    参考文献

    1. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67.

    2. Vestbo J, et al. Eur Respir J. 2009 May;33(5):1039-44.

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