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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Neprilysin-UK-414495
UK-414495

Chemical Structure : UK-414495

CAS No.: 337962-93-3

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UK-414495 (UK414495)

货号: PC-70064Not For Human Use, Lab Use Only.

A potent and selective inhibitor of neutral endopeptidase (NEP) with IC50 of 18.9 nM for hNEP.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A potent and selective inhibitor of neutral endopeptidase (NEP) with IC50 of 18.9 nM for hNEP; dose-dependently potentiates pelvic nerve-stimulated increases in VBF (EC50=37 nM); increases the amplitude and duration of VIP-induced increases in VBF in the anaesthetized rabbit.

物理化学性质&存储条件

分子量 339.453
分子式 C16H25N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[1-[[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]carbonyl]cyclopentyl]methyl]pentanoic acid

参考文献

1. Pryde DC, et al. J Med Chem. 2006 Jul 13;49(14):4409-24.

2. Wayman CP, et al. Br J Pharmacol. 2010 May;160(1):51-9.

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