UK-396082 | TAFIa inhibitor | Probechem Biochemicals

Chemical Structure : UK-396082

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UK-396082 (UK 396,082, UK396082)

货号: PC-61820Not For Human Use, Lab Use Only.

UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI, TAFIa) with Ki of 10 nM.

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生物&药学活性

UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI, TAFIa) with Ki of 10 nM.
UK-396082 displays excellent selectivity over plasma carboxypeptidase N (>1,000-fold).
UK-396082 exhibits antithrombotic efficacy in a rabbit model of venous thrombosis, yet has no effect on surgical bleeding in the rabbit.
UK-396082 possesses excellent preclinical and clinical pharmacokinetic profile, and shows potential for the treatment of thrombosis and other fibrin-dependent diseases in humans.

物理化学性质&存储条件

分子量	239.319
分子式	C12H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid

参考文献

1. Bunnage ME, et al. J Med Chem. 2007 Nov 29;50(24):6095-103.

2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24;32(5):277-87.

3. Bridge K, et al. PLoS One. 2017 May 4;12(5):e0177117.

UK-396082 (UK 396,082, UK396082)

生物&药学活性

物理化学性质&存储条件

参考文献

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UK-396082 (UK 396,082, UK396082)

生物&药学活性

物理化学性质&存储条件

参考文献

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