欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-UK-101
UK-101

Chemical Structure : UK-101

CAS No.: 1000313-40-5

加入收藏

UK-101 (UK 101, UK101)

货号: PC-60966Not For Human Use, Lab Use Only.

UK-101 is a potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.

规格 价格 库存 数量
1 mg ￥3980 In stock
5 mg ￥7580 In stock
10 mg Get quote
25 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UK-101 is a potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.
UK-101 induces apoptosis of PC-3 cells and results in significant inhibition (~50-60%) of tumour growth in vivo.
UK-101 does not block degradation of IκBα in PC-3 cells treated with TNF-α.

物理化学性质&存储条件

分子量 484.753
分子式 C25H48N2O5Si
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((S)-1-(((S)-1-((S)-2-(((tert-butyldimethylsilyl)oxy)methyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)heptanamide

参考文献

1. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

2. Wehenkel M, et al. Br J Cancer. 2012 Jun 26;107(1):53-62.

3. Lei B, et al. J Phys Chem B. 2010 Sep 30;114(38):12333-9.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: