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首页-小分子抑制剂&激动剂-Epigenetics-DNA Methyltransferase (DNMT)-UHRF1 inhibitor UM63
UHRF1 inhibitor UM63

Chemical Structure : UHRF1 inhibitor UM63

CAS No.: 117-77-1

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UHRF1 inhibitor UM63 (UM63)

货号: PC-72248Not For Human Use, Lab Use Only.

UHRF1 inhibitor UM63 (UM63) is an anthraquinone compound that binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, inhibits the base-flipping process, which is crucial in the replication of DNA methylation profiles.

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100 mg ￥3880 In stock
500 mg ￥6880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UHRF1 inhibitor UM63 (UM63) is an anthraquinone compound that binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, inhibits the base-flipping process, which is crucial in the replication of DNA methylation profiles.
UM63 impaired the UHRF1/DNMT1 interaction and decreased the overall methylation of DNA in treated cells.

物理化学性质&存储条件

分子量 239.23
分子式 C14H9NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-3-hydroxyanthracene-9,10-dione

参考文献

1. Liliyana Zaayter, et al. Chemistry. 2019 Oct 17;25(58):13363-13375.

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