UHC1 |CAS:1629960-95-7 Probechem Biochemicals

Chemical Structure : UHC1

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UHC1 (UHC-1;UHC 1)

货号: PC-60334Not For Human Use, Lab Use Only.

UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.

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生物&药学活性

UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.
UHC1 binds directly to the LBD of PPARγ with IC50 of 800 nM, more potently blocks CDK5-mediated PPARγ phosphorylation at Ser-273 compared with SR-1664.
UHC1 effectively ameliorates the inflammatory response both in vitro and in high-fat diet-fed mice, dramatically improved insulin sensitivity without causing fluid retention and weight gain.

物理化学性质&存储条件

分子量	489.575
分子式	C31H27N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4'-((2,3-dimethyl-5-((pyridin-3-ylmethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

参考文献

1. Choi SS, et al. J Biol Chem. 2014 Sep 19;289(38):26618-29.

UHC1 (UHC-1;UHC 1)

生物&药学活性

物理化学性质&存储条件

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UHC1 (UHC-1;UHC 1)

生物&药学活性

物理化学性质&存储条件

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