UFSP2 inhibitor compound-8 | UFSP2 inhibitor | Probechem Biochemicals

Chemical Structure : UFSP2 inhibitor compound-8

CAS No.: 850188-43-1

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UFSP2 inhibitor compound-8 (UFSP2 inhibitor)

货号: PC-20117Not For Human Use, Lab Use Only.

UFSP2 inhibitor compound-8 is a small molecule covalent inhibitor of UFSP2 (UFM1 Specific Peptidase 2), binds to Cys294 of UFSP2, promotes the protein modification by Ubiquitin-fold modifier 1 (UFM1) (UFMylation) of PD-L1 and destabilizes PD-L1.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UFSP2 inhibitor compound-8 is a small molecule covalent inhibitor of UFSP2 (UFM1 Specific Peptidase 2), binds to Cys294 of UFSP2, promotes the protein modification by Ubiquitin-fold modifier 1 (UFM1) (UFMylation) of PD-L1 and destabilizes PD-L1.

Compound-8 (5 μg/mL) could significantly and consistently improve the global UFMylation activity in both MDA-MB-231 and MC38 cells.

Compound-8 (5-15 μg/mL)decreased the expression of PD-L1 without affecting the UFSP2 protein levels.

Compound-8 dose dependently enhanced the global UFMylation proteins while decreasing the expression of PD-L1.

Compound-8 imparts tumor immune evasion in vivo, exhibits better antitumor effect with no appreciable body weight loss when combined with PD-1 blockade.

UFSP2 is the primary "de-UFMylation" enzyme in human cells, UFSP2 acts as a de-UFMylation enzyme for PD-L1 through direct physical interaction.

物理化学性质&存储条件

分子量	209.64
分子式	C6H8ClNO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)acetamide

参考文献

1. Zhou J, et al. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2215732120.

UFSP2 inhibitor compound-8 (UFSP2 inhibitor)

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物理化学性质&存储条件

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UFSP2 inhibitor compound-8 (UFSP2 inhibitor)

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物理化学性质&存储条件

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