UD-051

Chemical Structure : UD-051

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货号: PC-24918Not For Human Use, Lab Use Only.

UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM.

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100 mg		Get quote

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生物&药学活性

UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM.
UD-051 significantly ameliorated the progressive phenotype of Alport syndrome mouse model in an Nrf2-dependent manner。
UD-051 suppressed tubular injury, including oxidative stress, inflammation, and dysregulated metabolism.
UD-051 with losartan, a renin-angiotensin system inhibitor that targets glomerular dysfunction, vastly ameliorated Alport kidney disease.

物理化学性质&存储条件

分子量	577.73
分子式	C35H39N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino[7,6-g]quinolin-4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid

参考文献

1. Kaseda S, et al. Life Sci Alliance. 2025 Jun 17;8(8):e202503330.

UD-051

生物&药学活性

物理化学性质&存储条件

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UD-051

生物&药学活性

物理化学性质&存储条件

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