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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI4K-UCT943
UCT943

Chemical Structure : UCT943

CAS No.: 1450666-80-4

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UCT943 (UCT 943, UCT-943)

货号: PC-35292Not For Human Use, Lab Use Only.

UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM.

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2 mg ￥2480 In stock
5 mg ￥3980 In stock
10 mg ￥5780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM.
UCT943 displays higher asexual blood stage, transmission-blocking, and liver stage activity than MMV048 and is more potent against resistant P. falciparum and P. vivax clinical isolates.
UCT943 demonstrates excellent in vitro antiplasmodial activity in P. berghei and humanized P. falciparum mouse models.

物理化学性质&存储条件

分子量 427.431
分子式 C22H20F3N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(piperazin-1-yl)methanone

参考文献

1. Brunschwig C, et al. Antimicrob Agents Chemother. 2018 Jun 25. pii: AAC.00012-18.

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