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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glutamate Transporter-UCPH-101
UCPH-101

Chemical Structure : UCPH-101

CAS No.: 1118460-77-7

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UCPH-101 (UCPH101)

货号: PC-62148Not For Human Use, Lab Use Only.

UCPH-101 is a selective non-substrate inhibitor of EAAT1 (Excitatory amino acid transporter 1) with IC50 of 660 nM.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UCPH-101 is a selective non-substrate inhibitor of EAAT1 (Excitatory amino acid transporter 1) with IC50 of 660 nM.
UCPH-101 dispalys >50-fold selectivity over EAAT2 and EAAT3, and has no significant inhibition at EAAT4 or EAAT5.

物理化学性质&存储条件

分子量 422.48
分子式 C27H22N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile

参考文献

1. Canul-Tec JC, et al. Nature. 2017 Apr 27;544(7651):446-451.

2. Jensen AA, et al. J Med Chem. 2009 Feb 26;52(4):912-5.

3. Abrahamsen B, et al. J Neurosci. 2013 Jan 16;33(3):1068-87.

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