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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-UCP1173
UCP1173

Chemical Structure : UCP1173

CAS No.: 1922152-09-7

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UCP1173

货号: PC-27160Not For Human Use, Lab Use Only.

UCP1173 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 14 nM, 190 nM, 270 nM and 91 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, potent activity against MRSA strains possessing dfrA with MIC values of 1.25 and 2.5 ug/mL.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UCP1173 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 14 nM, 190 nM, 270 nM and 91 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, potent activity against MRSA strains possessing dfrA with MIC values of 1.25 and 2.5 ug/mL.

物理化学性质&存储条件

分子量 416.48
分子式 C24H24N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

参考文献

1. Reeve SM, et al. Cell Chem Biol. 2016;23(12):1458-1467.

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