UCP1172 | DHFR inhibitor, Antifolate | Probechem Biochemicals

Chemical Structure : UCP1172

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UCP1172 (UCP-1172)

货号: PC-27159Not For Human Use, Lab Use Only.

UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG).

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生物&药学活性

UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG).

物理化学性质&存储条件

分子量	416.48
分子式	C24H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

参考文献

1. Reeve SM, et al. Cell Chem Biol. 2016;23(12):1458-1467.

UCP1172 (UCP-1172)

生物&药学活性

物理化学性质&存储条件

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UCP1172 (UCP-1172)

生物&药学活性

物理化学性质&存储条件

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