UCM710 | FAAH/ABHD6 inhibitor | Probechem Biochemicals

Chemical Structure : UCM710

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UCM710 (Glycidyl Palmitoleate, UCM-710)

货号: PC-20128Not For Human Use, Lab Use Only.

UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity.

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生物&药学活性

UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity.
UCM710 dose-dependently inhibited AEA hydrolysis by FAAH and 2-AG hydrolysis by ABHD6 (IC50 = 4.0 and 2.4 μm, respectively) and had no effect on 2-AG hydrolysis by MAGL, also did not interact with CB1 and CB2 receptors.
UCM710 efficiently inhibited endocannabinoid (eCB) hydrolysis in neuron homogenates.

物理化学性质&存储条件

分子量	310.48
分子式	C19H34O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	oxiran-2-ylmethyl (Z)-hexadec-9-enoate

参考文献

1. William R Marrs, et al. J Biol Chem. 2011 Aug 19;286(33):28723-28728.

UCM710 (Glycidyl Palmitoleate, UCM-710)

生物&药学活性

物理化学性质&存储条件

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UCM710 (Glycidyl Palmitoleate, UCM-710)

生物&药学活性

物理化学性质&存储条件

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