UCM53

Chemical Structure : UCM53

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货号: PC-25152Not For Human Use, Lab Use Only.

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生物&药学活性

UCM53 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 1.3 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 13 uM.
UCM53 induces filamentation of B. subtilis cells, indicating inhibition of cell division.
UCM53 induces FtsZ delocalization with formation of numerous punctuate foci and distorted ring structures.
UCM53 is active on methicillin-resistant Staphylococcus aureus, ampicillin- and levofloxacin-resistant Enterococcus faecium, and levofloxacin-resistant Enterococcus faecalis and weakly active on Streptococcus pneumoniae.
UCM53 competitively inhibits GTP binding to FtsZ, effectively inhibits the growth of Gram-positive pathogens.

物理化学性质&存储条件

分子量	469.27
分子式	C24H14Cl2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	naphthalene-1,3-diyl bis(3-chloro-4-hydroxybenzoate)

参考文献

1. Ruiz-Avila LB, et al. ACS Chem Biol. 2013 Sep 20;8(9):2072-83.

UCM53

生物&药学活性

物理化学性质&存储条件

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UCM53

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