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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-FAAH-UCM1341
UCM1341

Chemical Structure : UCM1341

CAS No.: 2244611-73-0

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UCM1341 (UCM 1341)

货号: PC-49841Not For Human Use, Lab Use Only.

UCM1341 (UCM 1341) is a bivalent ligand with melatonin receptor agonist (hMT1/hMT2, pKi=9.11/8.77) and fatty acid amide hydrolase (FAAH) inhibitory activity (rFAAH IC5=0.85 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UCM1341 (UCM 1341) is a bivalent ligand with melatonin receptor agonist (hMT1/hMT2, pKi=9.11/8.77) and fatty acid amide hydrolase (FAAH) inhibitory activity (rFAAH IC5=0.85 nM).
    UCM1341 exhibited greater neuroprotection against neuroinflammatory degeneration, compared with the reference compounds URB597 (FAAH inhibitor) and melatonin.
    UCM1341 augmented the levels of anandamide and N-oleoylethanolamine, but not N-palmitoylethanolamine, up-regulated PPAR-α levels, attenuated demyelination and prevented the release of TNF-α, during neuroinflammation.
    UCM1341 modulated inflammatory responses by contributing to microglia/macrophage polarization, stimulating formation of lipid-laden macrophages and regulating expression of proteins controlling cholesterol metabolism and efflux.

    物理化学性质&存储条件

    分子量 592.53
    分子式 C31H34BrN3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [1,1'-biphenyl]-3-yl (6-((3-(2-acetamidoethyl)-2-bromo-1H-indol-5-yl)oxy)hexyl)carbamate

    参考文献

    1. Gilberto Spadoni, et al. J Med Chem. 2018 Sep 13;61(17):7902-7916.

    2. Cammarota M, et al. Br J Pharmacol. 2022 Dec 16. doi: 10.1111/bph.16014.

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