UCM-A86

Chemical Structure : UCM-A86

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货号: PC-26121Not For Human Use, Lab Use Only.

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生物&药学活性

UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors.
UCM-A86 selectively potentiates GluN1/GluN3A and GluN1/GluN3B receptors by 436% and 174%, respectively, relative to activation by glycine, with no activity at GluN1/GluN2A-D receptors.
UCM-A86 selectively potentiates responses from native GluN1/GluN3A receptors expressed in somatostatin-expressing interneurons of the somatosensory cortex with no modulation of hippocampal AMPA receptor-mediated and GluN1/2 NMDA receptor-mediated excitatory postsynaptic currents.
UCM-A86 demonstrates specific modulation of GluN3-containing NMDA receptors without affecting GluN2-containing NMDA receptors or AMPA receptors.

物理化学性质&存储条件

分子量	338.35
分子式	C15H13F3N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((4-isopropylphenyl)thio)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine

参考文献

1. Benton AJ, et al. Mol Pharmacol. 2026 Jan 23;108(3):100103.

UCM-A86

生物&药学活性

物理化学性质&存储条件

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UCM-A86

生物&药学活性

物理化学性质&存储条件

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