UCM-13369 | NPM1 inhibitor | Probechem Biochemicals

Chemical Structure : UCM-13369

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UCM-13369 (UCM13369)

货号: PC-22442Not For Human Use, Lab Use Only.

UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs.
UCM-13369 binds specifically to the C-end domain of the C+ mutant protein.
UCM-13369 inhibits gene and mutant NPM1 C+ protein expression and restores nucleolar localization.
UCM-13369 has efficacy against AML cell lines and primary cells.
UCM-13369 triggers apoptosis in AML cell lines and primary cells from AML patients and reduces tumor infiltration in a mouse model of AML with NPM1 C+ mutation.
UCM-13369 (50 mg/kg, tail vein injection) shows efficacy against AML cells in vivo.

物理化学性质&存储条件

分子量	389.54
分子式	C25H31N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4R)-4-(2-((cyclopropylmethyl)amino)ethyl)-2-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

参考文献

1. Sergio Algar, et al. JACS Au. 2024 Feb 9;4(5):1786-1800.

UCM-13369 (UCM13369)

生物&药学活性

物理化学性质&存储条件

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UCM-13369 (UCM13369)

生物&药学活性

物理化学性质&存储条件

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