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首页-小分子抑制剂&激动剂-Others-Other Targets-UCM-1336
UCM-1336

Chemical Structure : UCM-1336

CAS No.: 1621535-90-7

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UCM-1336 (UCM1336)

货号: PC-26955Not For Human Use, Lab Use Only.

UCM-1336 is a potent, selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with IC50 of 2 uM.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UCM-1336 is a potent, selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with IC50 of 2 uM.
UCM-1336 is selective against the other enzymes involved in the post-translational modifications of Ras.
UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways.
UCM-1336 induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia.
UCM-1336 impairs the activity of the four Ras isoforms regardless of its activating mutation.

物理化学性质&存储条件

分子量 423.60
分子式 C26H37N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,3'-(Octylazanediyl)bis(N-phenylpropanamide)

参考文献

1. Marín-Ramos NI, et al. J Med Chem. 2019 Jul 11;62(13):6035-6046.

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