UCM-1306 | D1R PAM | Probechem Biochemicals

Chemical Structure : UCM-1306

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UCM-1306 (UCM1306)

货号: PC-49303Not For Human Use, Lab Use Only.

UCM-1306 (UCM1306) is a subtype-selective, non-covalent, orally bioavailable positive allosteric modulator of dopamine D1 receptor with EC50 of 60 nM.

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生物&药学活性

UCM-1306 (UCM1306) is a subtype-selective, non-covalent, orally bioavailable positive allosteric modulator of dopamine D1 receptor with EC50 of 60 nM.
UCM-1306 increases the dopamine maximal effect in a dose-dependent manner in human and mouse D1 receptors, is inactive in the absence of dopamine, does not display agonist activity.
UCM-1306 exhibits subtype selectivity over human D2, D3, D4, and D5 receptors.
UCM-1306 potentiates cocaine-induced locomotion and enhances l-DOPA recovery of decreased locomotor activity in reserpinized mice after oral administration.

物理化学性质&存储条件

分子量	279.329
分子式	C14H14FNO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(2'-(fluoromethoxy)-[1,1'-biphenyl]-4-yl)(imino)(methyl)-l6-sulfanone

参考文献

1. Javier García-Cárceles, et al. J Med Chem. 2022 Aug 31. doi: 10.1021/acs.jmedchem.2c00949.

UCM-1306 (UCM1306)

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物理化学性质&存储条件

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UCM-1306 (UCM1306)

生物&药学活性

物理化学性质&存储条件

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