UCI-LC0019 | mutant p53 reactivator | Probechem Biochemicals

Chemical Structure : UCI-LC0019

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UCI-LC0019 (UCI-LC 0019)

货号: PC-49217Not For Human Use, Lab Use Only.

UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H.

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生物&药学活性

UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H.
UCI-LC0019 rapidly induced apoptosis compare with APR-246.
UCI-LC0019 exhibits significantly increased solubility while maintaining activity and selectivity compare with UCI-LC0023.
UCI-LC0019 (3.3 mg/kg, 10 mg/kg, i.p.) exerted anti-tumor effect in tumor models, treatment with UCI-LC0019 resulted in a significant reduction of tumor volume in p53R175H carrying TOV112D tumors, did not significantly inhibit the growth of TOV112Dp53 / or HCT116 (p53 +/+) tumors.

物理化学性质&存储条件

分子量	278.311
分子式	C17H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(1H-benzo[d]imidazol-2-yl)-3-(3-methoxyphenyl)prop-2-en-1-one

参考文献

1. Geetha Durairaj, et al. Cell Chem Biol. 2022 Aug 9;S2451-9456(22)00275-6.

UCI-LC0019 (UCI-LC 0019)

生物&药学活性

物理化学性质&存储条件

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UCI-LC0019 (UCI-LC 0019)

生物&药学活性

物理化学性质&存储条件

参考文献

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