UCHL1 inhibitor 27 (IMP-1711-S)

Chemical Structure : UCHL1 inhibitor 27

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货号: PC-72220Not For Human Use, Lab Use Only.

UCHL1 inhibitor 27 is a potent, selective, covalent UCHL1 inhibitor with IC50 of 90 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UCHL1 inhibitor 27 (IMP-1711-S) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 90 nM.
UCHL1 inhibitor 27 (IMP-1711-S) demonstrated exquisite selectivity in a cross-screening against 20 DUBs.
UCHL1 inhibitor 27 (IMP-1711-S) demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=100 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.
UCHL1 inhibitor 27 (IMP-1711-S) is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.
IMP-1711-S inhibited the production of IL-1β in a concentration-dependent manner in PMA-differentiated THP-1 cells and hiPSC-derived microglia.
IMP-1711-S potently inhibited gasdermin D (GSDMD) cleavage, the release of lactate dehydrogenase (LDH), and blocked pyroptotic cell death induced by Nig.
IMP-1711-S markedly downregulated the formation of NLRP3 specks in a concentration-dependent manner in HEK293 cells

物理化学性质&存储条件

分子量	357.417
分子式	C21H19N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile

参考文献

1. Kemp M, et al. WO 2017009650 (A1), 2017/01/19/, 2017.
2. Nattawadee Panyain, et al. J Am Chem Soc. 2020 Jul 15;142(28):12020-12026.
3. Zhu Liang, et al. Cell Rep. 2024 May 28;43(5):114152.