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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-UCB35625
UCB35625

Chemical Structure : UCB35625

CAS No.: 202796-42-7

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UCB35625 (UCB 35625, trans-J113863)

货号: PC-20541Not For Human Use, Lab Use Only.

UCB35625 is a potent, selective inhibitor of CCR1 and CCR3, inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM respectively.

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25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UCB35625 is a potent, selective inhibitor of CCR1 and CCR3, inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM respectively.
UCB35625 also inhibited the CCR3-mediated entry of the human immunodeficiency virus-1 primary isolate 89.6 into the glial cell line, NP-2 (IC50=57 nM).

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ClC1=CC=C(OC(C=CC(Cl)=C2)=C2C3C(N[C@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C3=C1.[I-]

参考文献

1. Sabroe I, et al. J Biol Chem. 2000 Aug 25;275(34):25985-92.

2. de Mendonça FL, et al. J Biol Chem. 2005 Feb 11;280(6):4808-16.

3. Ansari MA, et al. Immunobiology. 2022 Sep;227(5):152245.

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