UCB-9260 (UCB9260)

Chemical Structure : UCB-9260

CAS No.: 1515888-53-5

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货号: PC-73214Not For Human Use, Lab Use Only.

UCB-9260 is a specific, orally active compound, inhibits tumour necrosis factor (TNF) signaling by stabilising an asymmetric form of the trimer, binds to TNF with Kd of 13 nM.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

UCB-9260 is a specific, orally active compound, inhibits tumour necrosis factor (TNF) signaling by stabilising an asymmetric form of the trimer, binds to TNF with Kd of 13 nM.
UCB-9260 is selective for TNF over other superfamily members.
UCB-9260 inhibited TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM, and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.
UCB-9260 inhibited NF-κB with a geometric mean IC50 of 202 nM after TNF stimulation in HEK 293 cell-line.
UCB-9260 inhibited TNF-driven functional effects in vivo, showed a significant reduction of the clinical score in LPS challenged collagen antibody induced arthritis (CAIA) model.

物理化学性质&存储条件

分子量	423.51
分子式	C26H25N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-(2,5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol

参考文献

1. Daniel J Lightwood, et al. Nat Commun. 2021 Jan 25;12(1):583.

2. James O'Connell, et al. Nat Commun. 2019 Dec 19;10(1):5795.

UCB-9260 (UCB9260)

生物&药学活性

物理化学性质&存储条件

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UCB-9260 (UCB9260)

生物&药学活性

物理化学性质&存储条件

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