UC2288 | p21 inhibitor | Probechem Biochemicals

Chemical Structure : UC2288

CAS No.: 1394011-91-6

加入收藏

UC2288 (UC 2288)

货号: PC-49493Not For Human Use, Lab Use Only.

UC2288 is a small molecule p21 inhibitor, attenuates p21 protein abundance at 10 µM, independently of p53 activity and at the level of transcription or post-transcription.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

UC2288 is a small molecule p21 inhibitor, attenuates p21 protein abundance at 10 µM, independently of p53 activity and at the level of transcription or post-transcription.
UC2288 is a chemical analog of sorafenib, a multikinase inhibitor that also attenuates p21, but UC2288 does not inhibit Raf kinases or alter p-ERK protein levels.
UC2288 (10 uM) decreases p21 mRNA expression with no effect on p21 protein stability in 786-O cells.
UC2288 inhibits cell growth of various cancer cell lines, decreases cytosolic p21.

物理化学性质&存储条件

分子量	481.82
分子式	C20H18ClF6N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]urea

参考文献

1. Wettersten HI, et al. Cancer Biol Ther. 2013 Mar;14(3):278-85.

2. Tay VSY, et al. Sci Rep. 2019 Dec 18;9(1):19341.

3. Minagawa Y, et al. Anticancer Res. 2020 Oct;40(10):5631-5639.

UC2288 (UC 2288)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

UC2288 (UC 2288)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.