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首页-小分子抑制剂&激动剂-Others-Other Targets-UC1728
UC1728

Chemical Structure : UC1728

CAS No.: 948304-40-3

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UC1728 (t-TUCB, UC-1728)

货号: PC-35971Not For Human Use, Lab Use Only.

UC1728 (t-TUCB, UC-1728) is a potent and orally available inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 2.0 nM (rabbit liver sEH).

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UC1728 (t-TUCB, UC-1728) is a potent and orally available inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 2.0 nM (rabbit liver sEH).
UC1728 reduces ocular inflammation in a rabbit LPS-induced model of uveitis.

物理化学性质&存储条件

分子量 438.403
分子式 C21H21F3N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

trans-4-{4-[3-(4-Trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy}-benzoic acid

参考文献

1. McLellan GJ, et al. J Ocul Biol. 2016 Jan;4(1). doi: 10.13188/2334-2838.1000024.

2. Hwang SH, et al. J Med Chem. 2007 Aug 9;50(16):3825-40.

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