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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Ubiquitin-conjugating Enzyme (E2)-UC-764864
UC-764864

Chemical Structure : UC-764864

CAS No.: 2566480-62-2

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UC-764864 (UC764864)

货号: PC-72868Not For Human Use, Lab Use Only.

UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.
    UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
    Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

    物理化学性质&存储条件

    分子量 322.426
    分子式 C19H18N2OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-1-(4-ethylphenyl)-3-((6-methyl-1H-benzo[d]imidazol-2-yl)thio)prop-2-en-1-one

    参考文献

    1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.

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