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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-UC-514321
UC-514321

Chemical Structure : UC-514321

CAS No.: 299420-83-0

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UC-514321 (UC514321)

货号: PC-62519Not For Human Use, Lab Use Only.

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

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5 mg ￥1480 In stock
10 mg ￥2480 In stock
50 mg ￥5980 In stock
100 mg ￥8580 In stock
500 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
UC-514321 shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.

物理化学性质&存储条件

分子量 441.568
分子式 C26H35NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

参考文献

1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.

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