UBP792 | NMDAR NAM | Probechem Biochemicals

Chemical Structure : UBP792

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UBP792 (UBP-792)

货号: PC-49067Not For Human Use, Lab Use Only.

UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM.

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生物&药学活性

UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM.
UBP792 inhibits NMDAR responses by reducing l-glutamate and glycine potencies and efficacies.
UBP792 inhibition is not competitive with the structurally-related positive allosteric modulator (PAM) UBP684.
UBP792 inhibition is pH-dependent, voltage-independent and use-independent.
UBP792 requires opening of the GluN2 ligand-binding domain for activity, but not that of the GluN1 subunit.

物理化学性质&存储条件

分子量	335.315
分子式	C19H13NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-hydroxy-7-(2-nitrostyryl)-2-naphthoic acid

参考文献

1. Sapkota K, et al. Neuropharmacology. 2021 Dec 15;201:108818.

UBP792 (UBP-792)

生物&药学活性

物理化学性质&存储条件

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UBP792 (UBP-792)

生物&药学活性

物理化学性质&存储条件

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