UBP684 | NMDAR PAM | Probechem Biochemicals

Chemical Structure : UBP684

CAS No.: 1357838-47-1

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UBP684 (UBP-684)

货号: PC-49068Not For Human Use, Lab Use Only.

UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%.
UBP684 is use-independent pan-NMDA receptor allosteric potentiator.
UBP684 increases channel open probability and slows receptor deactivation.
UBP684 stabilizes the active form of the GluN2 ligand-binding domain.

物理化学性质&存储条件

分子量	256.345
分子式	C17H20O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-methylpent-1-yl)-2-naphthoic acid

参考文献

1. Sapkota K, et al. Neuropharmacology. 2017 Oct;125:64-79.

2. Chopra DA, et al. Sci Rep. 2017 Jul 31;7(1):6933.

3. Irvine MW, et al. Eur J Med Chem. 2019 Feb 15;164:471-498.

UBP684 (UBP-684)

生物&药学活性

物理化学性质&存储条件

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UBP684 (UBP-684)

生物&药学活性

物理化学性质&存储条件

参考文献

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