UBP310 | Kainate receptor antagoist | Probechem Biochemicals

Chemical Structure : UBP310

CAS No.: 902464-46-4

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UBP310 (UBP-310)

货号: PC-27551Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UBP310 is a high affinity, selective antagonist of kainate receptor GluR5 with Kd of 130 nM, has >800-fold selecitvity over GluR2 and GluR6, binds to GluK1 with KD of 21 nM, but shows no specific binding to GluK2.
UBP310 also effectively blocks recombinant homomeric GluK3 receptors, but not homomeric GluK2 or heteromeric GluK2/3 receptors.
UBP310 is an antagonist of recombinant GluK2/GluK5 receptors, significantly reduces the sustained depolarization and impacts on spike transmission mediated by heterosynaptic signals in hippocampal mossy fiber (MF) CA3 synapses.

物理化学性质&存储条件

分子量	353.35
分子式	C14H15N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((3-(2-Amino-2-carboxyethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)methyl)thiophene-2-carboxylic acid

参考文献

1. Mayer ML, et al. J Neurosci. 2006 Mar 15;26(11):2852-61.

2. Perrais D, et al. Neuropharmacology. 2009 Jan;56(1):131-40.

3. Atlason PT, et al. Mol Pharmacol. 2010 Dec;78(6):1036-45.

4. Pollok S, et al. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25851-25858.

UBP310 (UBP-310)

生物&药学活性

物理化学性质&存储条件

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UBP310 (UBP-310)

生物&药学活性

物理化学性质&存储条件

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